Pulsed drug delivery.

نویسندگان

  • Bruno G De Geest
  • Els Mehuys
  • Gert Laekeman
  • Jo Demeester
  • Stefaan C De Smedt
چکیده

Modern drug delivery aims to develop drug delivery systems that are able to meet specific therapeutic requirements. Whereas sustained drug release aims to maintain a constant drug level within the body, pulsed drug delivery intends to release the drug rapidly within a short period of time, as a result of a biological or external trigger, after a specific lag time. This editorial highlights some of the recent advances in new concepts for pulsed drug delivery and proposes some future strategies.

برای دانلود رایگان متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Towards an Implantable Pulsed Mode Electrolytic Drug Delivery System

This work presents a prototype of an implantable drug delivery system that delivers pulsed doses of a low solubility drug by pulling bodily fluid into a reservoir with the drug in solid form, allowing the drug to dissolve to its maximum co ncentration, and then ejecting the drug laced fluid back into the tissue. The cyclical actuation of the drug delivery sy stem is performed using an electroly...

متن کامل

A novel pulsed drug-delivery system: polyelectrolyte layer-by-layer coating of chitosan–alginate microgels

PURPOSE The aim of this report was to introduce a novel "core-membrane" microgel drug-delivery device for spontaneously pulsed release without any external trigger. METHODS The microgel core was prepared with alginate and chitosan. The semipermeable membrane outside the microgel was made of polyelectrolytes including polycation poly(allylamine hydrochloride) and sodium polystyrene sulfonate. ...

متن کامل

Pulsed Intra-Arterial Drug Injection during Diastolic Phase of Cardiac Function Increases Drug Efficacy by Enhancing Pharmacological Exposure of Targeted Tissues

Diastolic phase of cardiac function is associated with lower arterial flow and hence higher concentration of intra arterially injected drug is achieved at the site of injection. It is herein postulated that drugs show higher efficacy when injected during the diastolic phase of cardiac function. It is also postulated that this benefit cannot be achieved when the drug is injected with higher rate...

متن کامل

Enhanced Transdermal Delivery of Granisetron by Using Iontophoresis

     The purpose of the present study was to explore the passive and electrically assisted transdermal transport of Granisetron hydrochloride (GRA) in solution and gel formulation through iontophoresis and also the feasibility of delivering therapeutic amounts of drug for the treatment of chemotherapy-induced nausea and vomiting. In this study, iontophoretic permeation of GRA through guinea pig...

متن کامل

Enhanced Transdermal Delivery of Granisetron by Using Iontophoresis

     The purpose of the present study was to explore the passive and electrically assisted transdermal transport of Granisetron hydrochloride (GRA) in solution and gel formulation through iontophoresis and also the feasibility of delivering therapeutic amounts of drug for the treatment of chemotherapy-induced nausea and vomiting. In this study, iontophoretic permeation of GRA through guinea pig...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

عنوان ژورنال:
  • Expert opinion on drug delivery

دوره 3 4  شماره 

صفحات  -

تاریخ انتشار 2006